Kevin Schneider, on The Evangelist Speaks, points out that Inventor 11 supports 4 gb of RAM when running on a 64 bit OS and links to this FAQ on 64 bit Windows.
FAQ about Windows XP Professional x64 Edition - Microsoft
By Charlie Russel, Microsoft MVP for Windows Server, Security, and Tablet PC
Maybe worthwhile for Inventor but if you are running AutoCAD based software check out Shaan Hurley’s “Between The Lines ~ AutoCAD Blog” posts on 64 bit and AutoCAD before rushing out to get that new OS: